Introduction – Company Background
GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.
With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.
With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.
From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.
At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.
By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.
Core Strengths in Insole Manufacturing
At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.
Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.
We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.
With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.
Customization & OEM/ODM Flexibility
GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.
Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.
With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.
Quality Assurance & Certifications
Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.
We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.
Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.
ESG-Oriented Sustainable Production
At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.
To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.
We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.
Let’s Build Your Next Insole Success Together
Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.
From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.
Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.
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Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.
With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Graphene cushion OEM factory in Taiwan
Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.
We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.ODM service for ergonomic pillows China
At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.ODM service for ergonomic pillows Taiwan
📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Graphene sheet OEM supplier factory Taiwan
Researchers from the University of Georgia have found that monarch butterflies with more white spots on their wings are more likely to complete their long-distance migration to south and central Mexico. Monarch butterflies with larger white spots fly more efficiently, making long trips easier. A new study examined nearly 400 wild monarch wings and discovered that successful migrant monarchs had about 3% less black and 3% more white on their wings. The researchers hypothesize that the butterflies’ coloring is tied to the amount of solar radiation they receive during their migration, with the white spots improving their flight efficiency. However, with increasing temperatures and changes in solar radiation, these butterflies may have to adapt to maintain their migration success. If you’ve ever wondered how the monarch butterfly got its spots, University of Georgia researchers may have just found the answer. The new study suggests that the butterflies with more white spots are more successful at reaching their long-distance wintering destination. Although it’s not yet clear how the spots aid the species’ migration, it’s possible that the spots change airflow patterns around their wings. “We undertook this project to learn how such a small animal can make such a successful long-distance flight,” said lead author Andy Davis, an assistant researcher in UGA’s Odum School of Ecology. “We actually went into this thinking that monarchs with more dark wings would be more successful at migrating because dark surfaces can improve flight efficiency. But we found the opposite.” The monarchs with less black on their wings and more white spots were the ones that made it to their ultimate destination, nearly 3,000 miles (4,800 kilometers) away in south and central Mexico. “It’s the white spots that seem to be the difference maker,” Davis said. A University of Georgia study found that monarch butterflies with more white spots on their wings are more successful in their long-distance migration, likely due to improved flight efficiency through optimized solar energy absorption. However, climate change threatens this advantage, with higher solar intensity potentially reducing aerial efficiency. Migration Selects for Butterfly Spots The researchers analyzed nearly 400 wild monarch wings collected at different stages of their journey, measuring their color proportions. They found that successful migrant monarchs had about 3% less black and 3% more white on their wings. An additional analysis of museum specimens that included monarchs and six other butterfly species showed that the monarchs had significantly larger white spots than their nonmigratory cousins. The only other species that came close to having the same proportion of white spots on its wing was its semi-migratory relative, the southern monarch. Migratory monarchs have larger and more white spots than non-migratory relatives. Credit: Andrew K. Davis, using images courtesy of www.butterfliesofamerica.com with permission, CC-BY 4.0 Monarchs Use Solar Energy To Improve Flight The authors believe the butterflies’ coloring is related to the amount of radiation they receive during their journey. The monarchs’ longer journey means they’re exposed to more sunlight. As a result, they have evolved to have more white spots. “The amount of solar energy monarchs are receiving along their journey is extreme, especially since they fly with their wings spread open most of the time,” Davis said. “After making this migration for thousands of years, they figured out a way to capitalize on that solar energy to improve their aerial efficiency.” But as temperatures continue to rise and alter the solar radiation reaching Earth’s surface, monarchs will likely have to adapt to survive, said Mostafa Hassanalian, co-author of the study and an associate professor at the New Mexico Institute of Mining and Technology. “With greater solar intensity, some of that aerial efficiency could go away,” Davis said. “That would be yet one more thing that is hindering the species’ fall migration to Mexico.” Monarch Breeding Population Is Stable But it’s not all bad news for the flying insects. Davis’ previous work showed that summer populations of monarchs have remained relatively stable over the past 25 years. That finding suggests that the species’ population growth during the summer compensates for butterfly losses due to migration, winter weather and changing environmental factors. “The breeding population of monarchs seems fairly stable, so the biggest hurdles that the monarch population faces are in reaching their winter destination,” Davis said. “This study allows us to further understand how monarchs are successful in reaching their destination.” Reference: “How the monarch got its spots: Long-distance migration selects for larger white spots on monarch butterfly wings” by Andrew K. Davis, Brenden Herkenhoff, Christina Vu, Paola A. Barriga and Mostafa Hassanalian, 21 June 2023, PLOS ONE. DOI: 10.1371/journal.pone.0286921 Published in PLOS ONE, the study was co-authored by Christina Vu, from UGA’s Odum School of Ecology, and Paola A. Barriga, from UGA’s Department of Plant Biology; and Brenden Herkenhoff, from New Mexico Tech.
Researchers have found that neural networks, specifically through the molecule cyclic adenosine monophosphate (cAMP), play a pivotal role in regulating circadian rhythms. This revelation holds potential for new treatments for sleep disorders and health issues related to circadian rhythm disruptions. Research reveals that the molecule cAMP, regulated by the vasoactive intestinal peptide (VIP) in the brain’s SCN, is crucial for circadian rhythms, presenting potential new treatments for related health disorders. Circadian rhythms are inherent cycles lasting roughly 24 hours that regulate various biological processes, such as sleep and wakefulness. A research group at Nagoya University in Japan has recently revealed that neural networks play an important role in the regulation of circadian rhythms through the mediation of an intracellular molecule called cyclic adenosine monophosphate (cAMP). This discovery may pave the way for new strategies to treat sleep disorders and other chronic health conditions affected by disruption of the circadian rhythm. The research study was published in the journal Science Advances. Cellular Components and Their Functions In living things, almost every cell contains a biological clock that regulates the cycle of circadian rhythms. In mammals, a group of neurons that form a structure called the suprachiasmatic nucleus (SCN) is known as the master clock. It is located in the hypothalamus of the brain and synchronizes biological clocks in the peripheral tissues. Circadian rhythms are regulated by the transcription and translation mechanism of clock genes, which encode proteins that regulate daily cycles. However, some scientists suggest that in the SCN, so-called second messengers, such as cAMP and calcium ions, are also involved in the regulation of circadian rhythms. Second messengers are molecules that exist in a cell and mediate cell activity by relaying a signal from extracellular molecules. Insight From Dr. Daisuke Ono “The functional roles of second messengers in the SCN remain largely unclear,” said Dr. Daisuke Ono, the lead author of the study. “Among second messengers, cAMP is known as a particularly important molecule in various biological functions. Therefore, understanding the roles in the SCN may lead to new strategies for the treatment of sleep disorders and other health problems due to circadian rhythm disruption.” Optical images of cAMP (left) and calcium (right) in the suprachiasmatic nucleus. Credit: Daisuke Ono Research Methodology and Findings To investigate this issue, a Nagoya University research team led by Dr. Ono, in collaboration with Yulong Li of Peking University and Takashi Sugiyama of Evident Corporation, conducted a study focusing on cAMP in the SCN. The researchers first visualized the patterns of circadian rhythms of cAMP, using bioluminescent cAMP probes they developed. For comparison, they also visualized the rhythm patterns of calcium ions. When they blocked the function of a neural network, the rhythm of cAMP was lost, whereas the rhythm of calcium ions still existed. This suggests that in the SCN, the rhythm of cAMP is controlled by a neural network, while the rhythm of calcium ions is regulated by intracellular mechanisms. They next focused on an extracellular signaling molecule called vasoactive intestinal peptide (VIP). Its receptor is known to modulate cAMP in the SCN. To analyze how VIP affects the rhythm of cAMP, they inhibited VIP signaling. Their results showed a loss of the rhythm of cAMP, indicating that the intracellular cAMP rhythms are regulated by VIP in the SCN. If this is correct, then there should also be a circadian rhythm in the VIP release. To verify this, they introduced a G-protein-coupled receptor-activation-based (GRAB) VIP sensor using green fluorescent protein. Time-lapse imaging of the VIP release in the SCN revealed a clear circadian rhythm. Furthermore, this VIP release rhythm was abolished by blocking the function of a neural network. These results indicate that VIP is released rhythmically depending on neuronal activity and that the VIP release rhythm regulates the intracellular cAMP rhythm. Lastly, to determine how cAMP affects the rhythm of clock genes’ transcription and translation mechanisms, they conducted experiments using mice. They expressed a light-inducible enzyme called adenylate cyclase (bPAC) in the SCN slice and measured the protein level of the clock gene Per2, using bioluminescence imaging. They then irradiated the cells with blue light to verify the effect of cAMP on the circadian rhythm. The results showed that the manipulation of cAMP by blue light changed the circadian rhythm of the clock gene. They also manipulated the rhythm of cAMP in the SCN of living mice and found that the behavioral rhythm also shifted. These results suggest that intracellular cAMP affects both molecular and behavioral circadian rhythms that involve clock genes. Concluding Remarks “We concluded that intracellular cAMP rhythms in the SCN are regulated by VIP-dependent neural networks,” Ono explained. “Furthermore, the network-driven cAMP rhythm coordinates circadian molecular rhythms in the SCN as well as behavioral rhythms. In the future, we would like to elucidate the ancestral circadian clock, which is independent of clock genes and exists universally in life.” Reference: “Network-driven intracellular cAMP coordinates circadian rhythm in the suprachiasmatic nucleus” by Daisuke Ono, Huan Wang, Chi Jung Hung, Hsin-tzu Wang, Naohiro Kon, Akihiro Yamanaka, Yulong Li and Takashi Sugiyama, 4 January 2023, Science Advances. DOI: 10.1126/sciadv.abq7032 This work was supported by the Uehara Memorial Foundation, Kowa Life Science Foundation, Takeda Science Foundation, Kato Memorial Bioscience Foundation, DAIKO FOUNDATION, SECOM Science and Technology Foundation, Research Foundation for Opto-Science and Technology, The Nakatani Foundation for Advancement of Measuring Technologies in Biomedical Engineering, CASIO SCIENCE PROMOTION FOUNDATION, Innovation inspired by Nature” Research Support Program, SEKISUI CHEMICAL CO., LTD., Konica Minolta Science and Technology Foundation, The Inamori Foundation, Suntory Rising Stars Encouragement Program in life Sciences (SunRiSE) (to N.K.), JST FOREST Program (Grant Number JPMJFR211A, Japan), and the JSPS KAKENHI (21K19255, 21H02526, 21H00307, 21H00422, 20KK0177, 18H02477 to D.O.).
Australian researchers have discovered how COVID-19 can infect human placenta, revealing that the virus affects the syncytiotrophoblast cells, which are crucial for maintaining pregnancy. The study also found that anti-ACE2 antibodies and antiviral drugs can effectively prevent this infection, providing a significant advancement in understanding and potentially mitigating the effects of viral infections on pregnancy. Human skin cells reprogrammed into placental stem cells shows how COVID infects placenta — and how it can be stopped. In a landmark study published today (July 13) in the journal Nature Cell Biology, Australian researchers, led by Professor Jose Polo from Monash University and the University of Adelaide and University of Melbourne’s Professor Kanta Subbarao from the Peter Doherty Institute for Infection and Immunity (Doherty Institute), have revealed how COVID-19 can infect the human placenta. Research has shown that COVID-19 infections during pregnancy may lead to adverse outcomes, but little is known about the mechanisms behind the effects of SARS-CoV-2 infection in pregnancy. Placenta cells (syncytiotrophoblast, in green) infected with the SARS-CoV-2 virus (COVID-19, in red); blue areas are cell nuclei labeling the multinucleated syncytiotrophoblasts. Credit: Monash University The Australian research team grew placenta tissue in the lab, using a state-of-the-art method developed by Professor Polo and colleagues where human skin cells are “reprogrammed” into trophoblast stem cells (the cells that help a developing embryo attach to the wall of the uterus, forming part of the placenta). They found that ACE2, a protein that acts as the doorway for SARS-CoV-2 to enter organs such as the lung, is present in specific placental cells, like syncytiotrophoblasts (ST cells). Importantly, ST cells were susceptible to the virus – a major finding as these placental cells produce the key hormone for maintaining pregnancy (hCG). Dr. Joseph Chen, a stem cell biologist at Monash University and co-first author of the report, said this discovery explains several clinical reports indicating inflammation of the placenta due to COVID-19. “We observed that SARS-CoV-2 infection led to a significant reduction in the survival and differentiation of ST cells, which in turn resulted in lower production of hCG,” he said. “It suggests that this is how COVID-19 could impact pregnancy, though further investigations are needed.” Professor Jose Polo. Credit: Mike Rutherford Virologist at Doherty Institute and co-first author of the study Dr Jessica Neil said, “our team also discovered that anti-ACE2 antibodies and antiviral drugs were effective in preventing SARS-CoV-2 infection and restoring normal ST differentiation and function”. Professor Subbarao said that this study is a significant advance for the broader understanding of viral infections in pregnancy. “Our study provides valuable insights into the link between SARS-CoV-2 infection and placenta pathology. This is a game changer as we are now equipped to explore how the early placenta may be affected by other viruses as well,” she said. Professor Polo emphasized the importance of the research in establishing a platform to study early placental cell types. “This study not only helps us to understand what happens when the placenta is infected with the COVID-19 virus during pregnancy, it also means we have established a broader, scalable and tractable platform to study early placental cell types,” he said. Reference: “A placental model of SARS-CoV-2 infection reveals ACE2-dependent susceptibility and differentiation impairment in syncytiotrophoblasts” by J. Chen, J. A. Neil, J. P. Tan, R. Rudraraju, M. Mohenska, Y. B. Y. Sun, E. Walters, N. G. Bediaga, G. Sun, Y. Zhou, Y. Li, D. Drew, P. Pymm, W. H. Tham, F. J. Rossello, G. Nie, X. Liu, K. Subbarao and J. M. Polo, 13 July 2023, Nature Cell Biology. DOI: 10.1038/s41556-023-01182-0
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